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Kisspeptin modulates sexual and emotional brain processing in humans

OPEN The Journal of clinical investigation | 24 Jan 2017

AN Comninos, MB Wall, L Demetriou, AJ Shah, SA Clarke, S Narayanaswamy, A Nesbitt, C Izzi-Engbeaya, JK Prague, A Abbara, R Ratnasabapathy, V Salem, GM Nijher, CN Jayasena, M Tanner, P Bassett, A Mehta, EA Rabiner, C Hönigsperger, MR Silva, OK Brandtzaeg, E Lundanes, SR Wilson, RC Brown, SA Thomas, SR Bloom and WS Dhillo
Abstract
Sex, emotion, and reproduction are fundamental and tightly entwined aspects of human behavior. At a population level in humans, both the desire for sexual stimulation and the desire to bond with a partner are important precursors to reproduction. However, the relationships between these processes are incompletely understood. The limbic brain system has key roles in sexual and emotional behaviors, and is a likely candidate system for the integration of behavior with the hormonal reproductive axis. We investigated the effects of kisspeptin, a recently identified key reproductive hormone, on limbic brain activity and behavior.
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Concepts
Motivation, Reproduction, Puberty, Male, Human, Emotion, Limbic system, Psychology
MeSH headings
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