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R Triche and BR Mandelbaum
Abstract
This article reviews the basics of articular cartilage biology, which provide a necessary foundation for understanding the evolving field of articular cartilage injury and repair. The currently popular treatment options for osteochondral injury (microfracture, osteochondral autograft transfer system, osteochondral allograft, autologous chondrocyte implantation, and the use of scaffolds with autologous chondrocyte implantation) document the significant advances made in this area in the past 2 decades. Integration of newly available information and technology derived from advances in molecular biology and tissue engineering holds even greater promise for continued advances in optimal management of this challenging problem.
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Concepts
Biology, Knee cartilage replacement therapy, Evolution, DNA, Extracellular matrix, Molecular biology, Cartilage, Autologous chondrocyte implantation
MeSH headings
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