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PC Woo, CW Lam, EW Tam, CK Leung, SS Wong, SK Lau and KY Yuen
Abstract
The genome of P. marneffei, the most important thermal dimorphic fungus causing respiratory, skin and systemic mycosis in China and Southeast Asia, possesses 23 polyketide synthase (PKS) genes and 2 polyketide synthase nonribosomal peptide synthase hybrid (PKS-NRPS) genes, which is of high diversity compared to other thermal dimorphic pathogenic fungi. We hypothesized that the yellow pigment in the mold form of P. marneffei could also be synthesized by one or more PKS genes.
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Concepts
Southeast Asia, Polyketide synthase, Ascomycota, Amino acid, Penicillium, Nonribosomal peptide, Bacteria, Fungus
MeSH headings
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