OPEN PloS one | 20 Jul 2012
L Franco, C Sánchez, R Bravo, AB Rodríguez, C Barriga, E Romero and J Cubero
The hop (Humulus lupulus L.), a component of beer, is a sedative plant whose pharmacological activity is principally due to its bitter resins, in particular to the α-acid degradation product 2-methyl-3-buten-2-ol. The mechanism of action of hop resin consists of raising the levels of the neurotransmitter γ-aminobutyric acid (GABA), an inhibitory neurotransmitter acting in the central nervous system (CNS).
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