Efficacy of Sterile Fecal Filtrate Transfer for Treating Patients With Clostridium difficile Infection
OPEN Gastroenterology | 22 Nov 2016
SJ Ott, GH Waetzig, A Rehman, J Moltzau-Anderson, R Bharti, JA Grasis, L Cassidy, A Tholey, H Fickenscher, D Seegert, P Rosenstiel and S Schreiber
Fecal microbiota transplantation (FMT) is a highly effective therapy for recurrent Clostridium difficile infection (CDI). However, transferring undefined living bacteria entails uncontrollable risks for infectious and metabolic or malignant diseases, particularly in immunocompromised patients. We investigated whether sterile fecal filtrates (containing bacterial debris, proteins, antimicrobial compounds, metabolic products and oligonucleotides/DNA), rather than intact microorganisms, are effective in patients with CDI.
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