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MM Goheen, R Wegmüller, A Bah, B Darboe, E Danso, M Affara, D Gardner, JC Patel, AM Prentice and C Cerami
Abstract
Iron deficiency causes long-term adverse consequences for children and is the most common nutritional deficiency worldwide. Observational studies suggest that iron deficiency anemia protects against Plasmodiumfalciparum malaria and several intervention trials have indicated that iron supplementation increases malaria risk through unknown mechanism(s). This poses a major challenge for health policy. We investigated how anemia inhibits blood stage malaria infection and how iron supplementation abrogates this protection.
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Concepts
Transferrin, Immune system, Sickle-cell disease, Plasmodium falciparum, Iron deficiency anemia, Hemoglobin, Malaria, Red blood cell
MeSH headings
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