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Five new phenolic glycosides from Hedyotis scandens

Bioorganic & medicinal chemistry letters | 22 Jan 2013

GC Wang, T Li, FY Deng, YL Li and WC Ye
Abstract
Five new phenolic glycosides, hedyotosides A-E (1-5), including a new cyanogenic glycoside (1), along with 10 known compounds (6-15) were isolated from the whole plants of Hedyotis scandens. The structures of compounds 1-5 were established by extensive spectroscopic analyses and acid hydrolysis. All the isolated compounds were evaluated for their in vitro antiviral activity against respiratory syncytial virus (RSV) with cytopathic effect (CPE) reduction assay. Compounds 6 and 15 showed anti-RSV effects with IC(50) values of 20 and 25μg/mL, respectively.
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Concepts
Glycosides, Cardiac glycoside, Protein, Cyanide, Microbiology, Quercetin, Human respiratory syncytial virus, Glycoside
MeSH headings
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