Acute and chronic effects of cannabinoids on effort-related decision-making and reward learning: an evaluation of the cannabis ‘amotivational’ hypotheses
OPEN Psychopharmacology | 3 Sep 2016
W Lawn, TP Freeman, RA Pope, A Joye, L Harvey, C Hindocha, C Mokrysz, A Moss, MB Wall, MA Bloomfield, RK Das, CJ Morgan, DJ Nutt and HV Curran
Anecdotally, both acute and chronic cannabis use have been associated with apathy, amotivation, and other reward processing deficits. To date, empirical support for these effects is limited, and no previous studies have assessed both acute effects of Δ-9-tetrahydrocannabinol (THC) and cannabidiol (CBD), as well as associations with cannabis dependence.
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