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A Stefansdottir, ZC Johnston, N Powles-Glover, RA Anderson, IR Adams and N Spears
Abstract
As with many anti-cancer drugs, the topoisomerase II inhibitor etoposide is considered safe for administration to women in the second and third trimesters of pregnancy, but assessment of effects on the developing fetus have been limited. The purpose of this research was to examine the effect of etoposide on germ cells in the developing ovary. Mouse ovary tissue culture was used as the experimental model, thus allowing us to examine effects of etoposide on all stages of germ cell development in the same way, in vitro.
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Concepts
DNA, Puberty, Embryo, Cellular differentiation, Chemotherapy, Germ cell, Gene
MeSH headings
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