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Analysis of 25 C NBOMe in Seized Blotters by HPTLC and GC-MS

OPEN Journal of chromatographic science | 14 Jul 2016

B Duffau, C Camargo, M Kogan, E Fuentes and BK Cassels
Abstract
Use of unauthorized synthetic drugs is a serious, forensic, regulatory and public health issue. In this scenario, consumption of drug-impregnated blotters is very frequent. For decades, blotters have been generally impregnated with the potent hallucinogen known as lysergic acid diethylamide (LSD); however, since 2013 blotter stamps with N-2 methoxybenzyl-substituted phenylethylamine hallucinogen designated as “NBOMes” have been seized in Chile. To address this issue with readily accessible laboratory equipment, we have developed and validated a new HPTLC method for the identification and quantitation of 25-C-NBOMe in seized blotters and its confirmation by GC-MS. The proposed method was validated according to SWGTOX recommendations and is suitable for routine analysis of seized blotters containing 25-C-NBOMe. With the validated method, we analyzed 15 real samples, in all cases finding 25-C-NBOMe in a wide dosage range (701.0-1943.5 µg per blotter). In this situation, we can assume that NBOMes are replacing LSD as the main hallucinogenic drug consumed in blotters in Chile.
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Concepts
Ergoline, Psychedelic drug, Ergot, Psychedelics, dissociatives and deliriants, Drug, Lysergic acid, Lysergic acid diethylamide
MeSH headings
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