Mapping the structural organization of the brain in conduct disorder: replication of findings in two independent samples
OPEN Journal of child psychology and psychiatry, and allied disciplines | 17 Jun 2016
G Fairchild, N Toschi, K Sully, EJ Sonuga-Barke, CC Hagan, S Diciotti, IM Goodyer, AJ Calder and L Passamonti
Neuroimaging methods that allow researchers to investigate structural covariance between brain regions are increasingly being used to study psychiatric disorders. Structural covariance analyses are particularly well suited for studying disorders with putative neurodevelopmental origins as they appear sensitive to changes in the synchronized maturation of different brain regions. We assessed interregional correlations in cortical thickness as a measure of structural covariance, and applied this method to investigate the coordinated development of different brain regions in conduct disorder (CD). We also assessed whether structural covariance measures could differentiate between the childhood-onset (CO-CD) and adolescence-onset (AO-CD) subtypes of CD, which may differ in terms of etiology and adult outcomes.
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