Stabilising the Integrity of Snake Venom mRNA Stored under Tropical Field Conditions Expands Research Horizons
OPEN PLoS neglected tropical diseases | 10 Jun 2016
G Whiteley, RA Logan, KD Leung, FJ Newberry, PD Rowley, JP Dunbar, SC Wagstaff, NR Casewell and RA Harrison
Snake venoms contain many proteinaceous toxins that can cause severe pathology and mortality in snakebite victims. Interestingly, mRNA encoding such toxins can be recovered directly from venom, although yields are low and quality is unknown. It also remains unclear whether such RNA contains information about toxin isoforms and whether it is representative of mRNA recovered from conventional sources, such as the venom gland. Answering these questions will address the feasibility of using venom-derived RNA for future research relevant to biomedical and antivenom applications.
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