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Short Telomere Load, Telomere Length, and Subclinical Atherosclerosis: The PESA Study

OPEN Journal of the American College of Cardiology | 28 May 2016

JM Fernández-Alvira, V Fuster, B Dorado, N Soberón, I Flores, M Gallardo, S Pocock, MA Blasco and V Andrés
Abstract
Leucocyte telomere length (LTL) shortening is associated with cardiovascular ischemic events and mortality in humans, but data on its association with subclinical atherosclerosis are scarce. Whether the incidence and severity of subclinical atherosclerosis are associated with the abundance of critically short telomeres, a major trigger of cellular senescence, remains unknown.
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Concepts
Death, Radical, Maximum life span, Cell division, Immortality, Telomerase, Senescence, Telomere
MeSH headings
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