The New England journal of medicine | 26 May 2016
MA Johansson, L Mier-Y-Teran-Romero, J Reefhuis, SM Gilboa and SL Hills
Zika virus (ZIKV) infection during pregnancy has been linked to birth defects,(1) yet the magnitude of risk remains uncertain. Investigators studying the 2013-2014 Zika outbreak in French Polynesia estimated that the risk of microcephaly due to ZIKV infection in the first trimester of pregnancy was 0.95% (95% confidence interval, 0.34 to 1.91), on the basis of eight microcephaly cases identified retrospectively in a population of approximately 270,000 people with an estimated rate of ZIKV infection of 66%.(2) In the current outbreak, thousands of cases of infants with suspected microcephaly or other developmental anomalies of the central nervous system that may . . .
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