Nanoparticles coated with high molecular weight PEG penetrate mucus and provide uniform vaginal and colorectal distribution in vivo
Nanomedicine (London, England) | 14 May 2016
K Maisel, M Reddy, Q Xu, S Chattopadhyay, R Cone, LM Ensign and J Hanes
We previously reported that nanoparticles (NPs) coated with 10 kDa PEG were mucoadhesive. Here, we demonstrate that by increasing the surface density, PEG with molecular weight (MW) as high as 40 kDa can be used as a mucoinert NP surface coating.
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