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R Provenzano, A Besarab, CH Sun, SA Diamond, JH Durham, JL Cangiano, JR Aiello, JE Novak, T Lee, R Leong, BK Roberts, KG Saikali, S Hemmerich, LA Szczech, KP Yu and TB Neff
Abstract
Roxadustat (FG-4592), an oral hypoxia-inducible factor prolyl hydroxylase inhibitor that stimulates erythropoiesis, regulates iron metabolism, and reduces hepcidin, was evaluated in this phase 2b study for safety, efficacy, optimal dose, and dose frequency in patients with nondialysis CKD.
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Concepts
Hepcidin, Hematology, Iron deficiency anemia, Iron, Anemia, Anemia of chronic disease, Human iron metabolism
MeSH headings
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