Prolonged intralymphatic delivery of dendritic cells through implantable lymphatic ports in patients with advanced cancer
OPEN Journal for immunotherapy of cancer | 21 Apr 2016
M Radomski, HJ Zeh, HD Edington, JF Pingpank, LH Butterfield, TL Whiteside, E Wieckowski, DL Bartlett and P Kalinski
The currently-used modes of administration of immunotherapeutic agents result in their limited delivery to the lymph nodes and/or require repetitive ultrasound-guided nodal injections or microsurgical lymphatic injections, limiting their feasibility. Here, we report on the feasibility and safety of a new method of long-term repetitive intralymphatic (IL) infusion of immune cells, using implantable delivery ports.
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