Introducing precise genetic modifications into human 3PN embryos by CRISPR/Cas-mediated genome editing
Journal of assisted reproduction and genetics | 8 Apr 2016
X Kang, W He, Y Huang, Q Yu, Y Chen, X Gao, X Sun and Y Fan
As a powerful technology for genome engineering, the CRISPR/Cas system has been successfully applied to modify the genomes of various species. The purpose of this study was to evaluate the technology and establish principles for the introduction of precise genetic modifications in early human embryos.
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