SciCombinator

Discover the most talked about and latest scientific content & concepts.

R Casellas, U Basu, WT Yewdell, J Chaudhuri, DF Robbiani and JM Di Noia
Abstract
As B cells engage in the immune response, they express activation-induced cytidine deaminase (AID) to initiate the hypermutation and recombination of immunoglobulin genes, which are crucial processes for the efficient recognition and disposal of pathogens. However, AID must be tightly controlled in B cells to minimize off-target mutations, which can drive chromosomal translocations and the development of B cell malignancies, such as lymphomas. Recent genomic and biochemical analyses have begun to unravel the mechanisms of how AID-mediated deamination is targeted outside immunoglobulin genes. Here, we discuss the transcriptional and topological features that are emerging as key drivers of AID promiscuous activity.
Tweets*
9
Facebook likes*
1
Reddit*
0
News coverage*
1
Blogs*
0
SC clicks
1
Concepts
Adaptive immune system, Gene, Genetics, Cancer, Protein, Bacteria, Immune system, DNA
MeSH headings
-
comments powered by Disqus

* Data courtesy of Altmetric.com