Acta paediatrica (Oslo, Norway : 1992) | 5 Feb 2013
Q Zhang, J Qi, H Yan and J Du
AIM: This study was designed to evaluate the diagnostic value of B-type natriuretic peptide (BNP) in syncope in children and adolescents. METHODS: Serum BNP concentration was measured by electrochemiluminescence assay in 62 consecutive children and adolescents hospitalized for syncope. RESULTS: Of the 62 children and adolescents hospitalized for syncope, 39 had non-cardiac syncope, 37 (59.7%) of whom had autonomic-mediated reflex syncope, and two (3.2%) had syncope of unknown cause. Twenty-three patients (37.1%) had cardiac syncope; 11 of these had cardiac arrhythmias and 12 had structural cardiac/cardiopulmonary disease. Patients with cardiac syncope had significantly higher serum BNP than those with non-cardiac syncope (958.78 ± 2443.41 pg/ml vs. 31.05 ± 22.64 pg/ml, p < 0.05). Logistic multivariate regression analysis revealed that urinary incontinence during syncopal episodes, ECG abnormalities and increased serum BNP levels were independent predictors for cardiac syncope. At a cut-off value of 40.65 pg/ml, serum BNP was associated with significant risk for a cardiac cause of syncope, with sensitivity 73.9% and specificity 70.0% for distinguishing cardiac syncope from non-cardiac syncope. CONCLUSION: Serum BNP was helpful in differentiating cardiac syncope from non-cardiac syncope in children and adolescents ©2013 The Author(s)/Acta Paediatrica ©2013 Foundation Acta Paediatrica.
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