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LK Stamp, J Hazlett, RL Roberts, C Frampton, J Highton and PA Hessian
Abstract
Methotrexate (MTX) exerts at least part of its anti-inflammatory effects through adenosine receptors (ADOR). The aims of this study were to determine the expression of all four adenosine receptor genes (ADORA1, ADORA2A, ADORA2B, ADORA3 and ADORA3variant) in rheumatoid synovial tissue and any influence of MTX exposure on this expression. Furthermore, we investigated whether polymorphisms within ADORA3 were associated with response and/or adverse effects associated with MTX.
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Concepts
Adenosine receptors, Adenosine A2A receptor, Adenosine, Rheumatoid arthritis, Adenosine A1 receptor, Adenosine receptor
MeSH headings
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