OPEN The New England journal of medicine | 21 Jan 2016
One of the most important discoveries in the treatment of acute leukemia is that the presence of minimal residual disease is an independent prognostic factor for the duration of remission and survival. This is particularly true for patients with acute lymphoblastic leukemia.(1),(2) The identification of minimal residual disease at the end of induction therapy, at the end of consolidation therapy, or before allogeneic hematopoietic stem-cell transplantation in patients with acute lymphoblastic leukemia is associated with a significantly worse outcome than is the absence of minimal residual disease at the same time point.(1)-(3) The presence of minimal residual disease . . .
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