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Minimal Residual Disease in NPM1-Mutated AML

OPEN The New England journal of medicine | 21 Jan 2016

MJ Burke
Abstract
One of the most important discoveries in the treatment of acute leukemia is that the presence of minimal residual disease is an independent prognostic factor for the duration of remission and survival. This is particularly true for patients with acute lymphoblastic leukemia.(1),(2) The identification of minimal residual disease at the end of induction therapy, at the end of consolidation therapy, or before allogeneic hematopoietic stem-cell transplantation in patients with acute lymphoblastic leukemia is associated with a significantly worse outcome than is the absence of minimal residual disease at the same time point.(1)-(3) The presence of minimal residual disease . . .
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Concepts
Hematology, Medical terms, Organ transplant, Acute lymphoblastic leukemia
MeSH headings
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