Vitamin D associates with improved quality of life in participants with irritable bowel syndrome: outcomes from a pilot trial
OPEN BMJ open gastroenterology | 1 Jan 2016
S Tazzyman, N Richards, AR Trueman, AL Evans, VA Grant, I Garaiova, SF Plummer, EA Williams and BM Corfe
Vitamin D deficiency has been associated or implicated with the pathophysiology of the gastrointestinal conditions inflammatory bowel disease and colorectal cancer, as well as with depression. No trials or epidemiology studies to date have investigated a link with irritable bowel syndrome (IBS). A single case report has suggested a benefit in IBS of vitamin D supplementation. We hypothesised that IBS participants with vitamin D insufficiency would benefit from repletion in terms of their IBS symptoms. We undertook a pilot trial to provide data to support a power calculation and to justify a full trial.
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