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S Tazzyman, N Richards, AR Trueman, AL Evans, VA Grant, I Garaiova, SF Plummer, EA Williams and BM Corfe
Abstract
Vitamin D deficiency has been associated or implicated with the pathophysiology of the gastrointestinal conditions inflammatory bowel disease and colorectal cancer, as well as with depression. No trials or epidemiology studies to date have investigated a link with irritable bowel syndrome (IBS). A single case report has suggested a benefit in IBS of vitamin D supplementation. We hypothesised that IBS participants with vitamin D insufficiency would benefit from repletion in terms of their IBS symptoms. We undertook a pilot trial to provide data to support a power calculation and to justify a full trial.
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Concepts
Inflammation, Immune system, Constipation, Cancer, Gastroenterology, Ulcerative colitis, Irritable bowel syndrome, Vitamin D
MeSH headings
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