SciCombinator

Discover the most talked about and latest scientific content & concepts.

L McHugh, TA Seldon, RA Brandon, JT Kirk, A Rapisarda, AJ Sutherland, JJ Presneill, DJ Venter, J Lipman, MR Thomas, PM Klein Klouwenberg, L van Vught, B Scicluna, M Bonten, OL Cremer, MJ Schultz, T van der Poll, TD Yager and RB Brandon
Abstract
Systemic inflammation is a whole body reaction having an infection-positive (i.e., sepsis) or infection-negative origin. It is important to distinguish between these two etiologies early and accurately because this has significant therapeutic implications for critically ill patients. We hypothesized that a molecular classifier based on peripheral blood RNAs could be discovered that would (1) determine which patients with systemic inflammation had sepsis, (2) be robust across independent patient cohorts, (3) be insensitive to disease severity, and (4) provide diagnostic utility. The goal of this study was to identify and validate such a molecular classifier.
Tweets*
12
Facebook likes*
2
Reddit*
0
News coverage*
36
Blogs*
2
SC clicks
0
Concepts
Observation, Medical terms, Systemic inflammatory response syndrome, Patient, Sepsis, Illness, Medicine, Inflammation
MeSH headings
-
comments powered by Disqus

* Data courtesy of Altmetric.com