A Molecular Host Response Assay to Discriminate Between Sepsis and Infection-Negative Systemic Inflammation in Critically Ill Patients: Discovery and Validation in Independent Cohorts
OPEN PLoS medicine | 10 Dec 2015
L McHugh, TA Seldon, RA Brandon, JT Kirk, A Rapisarda, AJ Sutherland, JJ Presneill, DJ Venter, J Lipman, MR Thomas, PM Klein Klouwenberg, L van Vught, B Scicluna, M Bonten, OL Cremer, MJ Schultz, T van der Poll, TD Yager and RB Brandon
Systemic inflammation is a whole body reaction having an infection-positive (i.e., sepsis) or infection-negative origin. It is important to distinguish between these two etiologies early and accurately because this has significant therapeutic implications for critically ill patients. We hypothesized that a molecular classifier based on peripheral blood RNAs could be discovered that would (1) determine which patients with systemic inflammation had sepsis, (2) be robust across independent patient cohorts, (3) be insensitive to disease severity, and (4) provide diagnostic utility. The goal of this study was to identify and validate such a molecular classifier.
* Data courtesy of Altmetric.com