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JH Elliott, JH McMahon, CC Chang, SA Lee, W Hartogensis, N Bumpus, R Savic, J Roney, R Hoh, A Solomon, M Piatak, RJ Gorelick, J Lifson, P Bacchetti, SG Deeks and SR Lewin
Abstract
In vitro, disulfiram activated HIV transcription in a primary T-cell model of HIV latency and in a pilot clinical study increased plasma HIV RNA in individuals with adequate drug exposure. We assessed the effect of disulfiram on HIV transcription in a dose-escalation study.
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Concepts
Cytomegalovirus, Virus, Infectious disease, Clinical trial, Reverse transcriptase, Gene, Transcription, HIV
MeSH headings
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