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Effect of high-potency cannabis on corpus callosum microstructure

OPEN Psychological medicine | 27 Nov 2015

S Rigucci, TR Marques, M Di Forti, H Taylor, F Dell'Acqua, V Mondelli, S Bonaccorso, A Simmons, AS David, P Girardi, CM Pariante, RM Murray and P Dazzan
Abstract
The use of cannabis with higher ��9-tetrahydrocannabinol content has been associated with greater risk, and earlier onset, of psychosis. However, the effect of cannabis potency on brain morphology has never been explored. Here, we investigated whether cannabis potency and pattern of use are associated with changes in corpus callosum (CC) microstructural organization, in patients with first-episode psychosis (FEP) and individuals without psychosis, cannabis users and non-users. Method The CC of 56 FEP (37 cannabis users) and 43 individuals without psychosis (22 cannabis users) was virtually dissected and segmented using diffusion tensor imaging tractography. The diffusion index of fractional anisotropy, mean diffusivity (MD), axial diffusivity (AD) and radial diffusivity was calculated for each segment.
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Concepts
Cerebrum, Neuroimaging, Tensors, Agenesis of the corpus callosum, Imaging, Diffusion MRI, Corpus callosum, Magnetic resonance imaging
MeSH headings
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