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Abstract

Blood pressure is a potent determinant of cardiovascular risk, but the most appropriate targets for blood-pressure lowering have long been debated. Observational studies with a low risk of confounding have shown a linear relationship between blood pressure and cardiovascular risk down to 115/75 mm Hg,(1) but some observational studies with a greater potential for confounding, involving persons at increased risk, have suggested a J-shaped curve - that is, below a given blood pressure, risk would increase. When trials of blood-pressure-lowering drugs have shown benefits in patients without hypertension, these effects have often been ascribed to alternative mechanisms. The widespread uncertainty . . .

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Concepts

Prehypertension, Artery, Atherosclerosis, Hypertension, Blood pressure, Orthostatic hypotension, Blood, Myocardial infarction

MeSH headings

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