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J Le Noury, JM Nardo, D Healy, J Jureidini, M Raven, C Tufanaru and E Abi-Jaoude
Abstract
To reanalyse SmithKline Beecham’s Study 329 (published by Keller and colleagues in 2001), the primary objective of which was to compare the efficacy and safety of paroxetine and imipramine with placebo in the treatment of adolescents with unipolar major depression. The reanalysis under the restoring invisible and abandoned trials (RIAT) initiative was done to see whether access to and reanalysis of a full dataset from a randomised controlled trial would have clinically relevant implications for evidence based medicine.
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Concepts
Beecham, Avicenna, GlaxoSmithKline, The Canon of Medicine, Systematic review, Paroxetine, Major depressive disorder, Randomized controlled trial
MeSH headings
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