Activation of RANKL and Matrix Metalloproteinase Production in Periodontal Fibroblasts by Endothelin Signaling
Journal of periodontology | 18 Sep 2015
LB Ruest, H Ranjbaran, EJ Tong, KK Svoboda and JQ Feng
Periodontitis is a group of inflammatory diseases affecting the tissues supporting the teeth that will progressively cause the loss of alveolar bone and periodontal ligaments and eventually the dentition. Activation of osteoclast activity by RANKL and released enzymes such as matrix metalloproteinases (MMPs) are among the factors involved in the destruction of the periodontium. However, the mechanisms regulating their production in periodontitis are poorly understood. Endothelin signaling via the activation of the endothelin-A receptor (EDNRA) by endothelin-1 may play a role in the disease since the expression of the receptor and ligand is elevated in the periodontal tissues of patients with periodontitis.
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