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BY Kim, HR Park, HG Jeong and SW Kim
Abstract
Berberine (Ber), used widely as an antibacterial, antifungal, and anti-inflammatory drug, has long been used as a gastrointestinal remedy in Chinese traditional medicine. Recent reports have suggested that Ber suppresses Th17 responses that was mediated by direct actions on T cells and thymic stromal lymphopoietin production in primary mast cells. It has been suggested that Ber may be useful in treating allergic response. The purpose of this study was to assess the effects of Ber treatment on allergic inflammation in an allergic rhinitis mouse model and to examine the underlying mechanism(s).
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Concepts
Mast cell, Traditional Chinese medicine, Eicosanoid, Traditional Chinese characters, House dust mite, Immune system, Allergy, Asthma
MeSH headings
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