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A Volz, A Kupke, F Song, S Jany, R Fux, H Shams-Eldin, J Schmidt, C Becker, M Eickmann, S Becker and G Sutter
Abstract
Middle East Respiratory Syndrome coronavirus (MERS-CoV) causes severe respiratory disease in humans. We tested a recombinant MVA vaccine expressing full-length MERS-CoV spike glycoprotein (S) by immunizing BALB/c mice using either intramuscular or subcutaneous regimens. In all cases MVA-MERS-S induced MERS-CoV-specific CD8+ T-cells and virus-neutralizing antibodies. Vaccinated mice were protected against MERS-CoV challenge infection after transduction with the human dipeptidyl peptidase 4 receptor. This MERS-CoV infection model demonstrates the safety and efficacy of the candidate vaccine.
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Concepts
Modified vaccinia Ankara, Virology, Severe acute respiratory syndrome, Dipeptidyl peptidase-4, Asia, Smallpox, Virus, Immune system
MeSH headings
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