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CD169+ macrophages are sufficient for priming of CTLs with specificities left out by cross-priming dendritic cells

OPEN Proceedings of the National Academy of Sciences of the United States of America | 30 Apr 2015

CA Bernhard, C Ried, S Kochanek and T Brocker
Abstract
Dendritic cells (DCs) are considered the most potent antigen-presenting cells (APCs), which directly prime or cross-prime MHC I-restricted cytotoxic T cells (CTLs). However, recent evidence suggests the existence of other, as-yet unidentified APCs also able to prime T cells. To identify those APCs, we used adenoviral (rAd) vectors, which do not infect DCs but selectively accumulate in CD169(+) macrophages (MPs). In mice that lack DCs, infection of CD169(+) MPs was sufficient to prime CTLs specific for all epitopes tested. In contrast, CTL responses relying exclusively on cross-presenting DCs were biased to selected strong MHC I-binding peptides only. When both DCs and MPs were absent, no CTL responses could be elicited. Therefore, CD169(+) MPs can be considered APCs that significantly contribute to CTL responses.
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Concepts
Virus, White blood cell, Antigen, MHC class I, Antigen-presenting cell, Dendritic cell, Cytotoxic T cell, Immune system
MeSH headings
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