Effectiveness and cost-effectiveness of mindfulness-based cognitive therapy compared with maintenance antidepressant treatment in the prevention of depressive relapse or recurrence (PREVENT): a randomised controlled trial
OPEN Lancet | 25 Apr 2015
W Kuyken, R Hayes, B Barrett, R Byng, T Dalgleish, D Kessler, G Lewis, E Watkins, C Brejcha, J Cardy, A Causley, S Cowderoy, A Evans, F Gradinger, S Kaur, P Lanham, N Morant, J Richards, P Shah, H Sutton, R Vicary, A Weaver, J Wilks, M Williams, RS Taylor and S Byford
Individuals with a history of recurrent depression have a high risk of repeated depressive relapse or recurrence. Maintenance antidepressants for at least 2 years is the current recommended treatment, but many individuals are interested in alternatives to medication. Mindfulness-based cognitive therapy (MBCT) has been shown to reduce risk of relapse or recurrence compared with usual care, but has not yet been compared with maintenance antidepressant treatment in a definitive trial. We aimed to see whether MBCT with support to taper or discontinue antidepressant treatment (MBCT-TS) was superior to maintenance antidepressants for prevention of depressive relapse or recurrence over 24 months.
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