Attenuated Inflammatory Response in Triggering Receptor Expressed on Myeloid Cells 2 (TREM2) Knock-Out Mice following Stroke
OPEN PloS one | 10 Jan 2013
MW Sieber, N Jaenisch, M Brehm, M Guenther, B Linnartz-Gerlach, H Neumann, OW Witte and C Frahm
Triggering receptor expressed on myeloid cells-2 (TREM2) is a microglial surface receptor involved in phagocytosis. Clearance of apoptotic debris after stroke represents an important mechanism to re-attain tissue homeostasis and thereby ensure functional recovery. The role of TREM2 following stroke is currently unclear.
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