Broad Blockade Antibody Responses in Human Volunteers after Immunization with a Multivalent Norovirus VLP Candidate Vaccine: Immunological Analyses from a Phase I Clinical Trial
OPEN PLoS medicine | 25 Mar 2015
LC Lindesmith, MT Ferris, CW Mullan, J Ferreira, K Debbink, J Swanstrom, C Richardson, RR Goodwin, F Baehner, PM Mendelman, RF Bargatze and RS Baric
Human noroviruses (NoVs) are the primary cause of acute gastroenteritis and are characterized by antigenic variation between genogroups and genotypes and antigenic drift of strains within the predominant GII.4 genotype. In the context of this diversity, an effective NoV vaccine must elicit broadly protective immunity. We used an antibody (Ab) binding blockade assay to measure the potential cross-strain protection provided by a multivalent NoV virus-like particle (VLP) candidate vaccine in human volunteers.
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