OPEN The New England journal of medicine | 25 Dec 2012
M Gassner, R Gehrig and P Schmid-Grendelmeier
To the Editor: Changing patterns of allergic sensitization to pollens have been noted around the world among schoolchildren. We report one associated with unusual winter allergic symptoms in Switzerland. Our group has gathered information on allergic symptoms and serologic findings among 15-year-olds attending school in Grabs, a village in eastern Switzerland,(1) from 1983 through 2007.(2) We measured IgE antibodies to 103 molecular allergens (using ImmunoCAP ISAC) in serum samples obtained from 54 students in 1986 and from 46 students in 2006.(3) In 2010, we retested 12 of the former students (then 39 years old) who in 1986 had had positive . . .
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