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PG Ridge, TJ Maxwell, CD Corcoran, MC Norton, JT Tschanz, E O'Brien, RA Kerber, RM Cawthon, RG Munger and JS Kauwe
Abstract
Alzheimer’s disease (AD) is the most common cause of dementia and AD risk clusters within families. Part of the familial aggregation of AD is accounted for by excess maternal vs. paternal inheritance, a pattern consistent with mitochondrial inheritance. The role of specific mitochondrial DNA (mtDNA) variants and haplogroups in AD risk is uncertain.
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Concepts
Mitochondrial Eve, Paternal mtDNA transmission, Dementia, Cinderella effect, DNA, Mitochondrial DNA, Alzheimer's disease, Mitochondrion
MeSH headings
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