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DT Chien, S Bahri, AK Szardenings, JC Walsh, F Mu, MY Su, WR Shankle, A Elizarov and HC Kolb
Abstract
Aggregates of hyperphosphorylated tau (PHF-tau), such as neurofibrillary tangles, are linked to the degree of cognitive impairment in Alzheimer’s disease. We have developed a novel PHF-tau targeting positron emission tomography imaging agent, [F-18]-T807, which may be useful for imaging Alzheimer’s disease and other tauopathies. Here, we describe the first human brain images with [F-18]-T807.
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Concepts
Single photon emission computed tomography, Fluorine-18, Neurofibrillary tangle, Carbon-11, Positron, Neuroimaging, Alzheimer's disease, Positron emission tomography
MeSH headings
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