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Polycythemia Vera, the Hematocrit, and Blood-Volume Physiology

OPEN The New England journal of medicine | 12 Dec 2012

JL Spivak
Abstract
Marchioli et al.(1) report in the Journal that a hematocrit target of less than 45% for therapeutic phlebotomy reduces the risk of thrombosis in patients with polycythemia vera. In the genomic era, readers may question attention given to a measurement as mundane as the hematocrit, but this study resolves a half-century of debate about the role of phlebotomy in polycythemia vera and has ramifications for diagnosis and management. Polycythemia vera is a unique myeloproliferative disorder in which there is overproduction of morphologically normal erythrocytes, granulocytes, and platelets, a phenotype that is caused by a mutation (V617F) in JAK2, encoding . . .
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Concepts
Hematocrit, Polycythemia vera, Red blood cell, Blood, Hematology
MeSH headings
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